Core Papers

Aging Skin: Mechanisms and Treatments
Aging Skin: Mechanisms and Treatments

Aging Skin: Mechanisms and Treatments

Lisa E. Maier, Mandy Harting and John J. Voorhees

Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA

Published:  06 January 2010

 

Summary

Cutaneous aging is a result of endogenous and exogenous processes that damage the dermal extracellular matrix. This damage leads to many of the clinical features that are undesirable in aged skin. The most detrimental exogenous factor is ultraviolet light (UV), which increases cutaneous levels of matrix degrading enzymes known as matrix metalloproteinases. In this article, we review known mechanisms of UV-induced aging (photoaging) and chronological aging. We will discuss current treatments used to improve the appearance and function of aged skin.

 
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