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Outcomes and cost of prophylactic tacrolimus ointment in patients with moderate or severe atopic dermatitis

A Pan-European Phase III randomized trial compared the effects of prophylactic use of tacrolimus ointment 0.1% (PU) versus its conventional use (CU) twice weekly for 12 months in 134 patients with moderate to severe atopic dermatitis (AD). In patients with moderate AD, the number of disease exacerbations was significantly lower in the PU versus the CU arm (2.4 vs. 5.5, respectively; p<0.05). In patients with severe AD, the corresponding values were 2.3 versus 7.4, respectively (p<0.05). In moderately affected patients the mean total annual cost/patient in the PU arm was €1525 versus €1729 in the CU arm. In severe AD patients the corresponding values were €2045 and €2904, respectively. Prophylactic tacrolimus ...