A prospective, observational, multicenter study gathered information on the effectiveness and safety of imiquimod 5% cream in 370 adults with superficial basal cell carcinoma in daily practice. Patient satisfaction was also assessed. Imiquimod was applied 5 times weekly for 6 weeks; patients recorded treatment events on diary cards and had a final visit within 16 weeks of the end of treatment. In total, 471 tumors were evaluated, most of which were primary. The clearance rate was 83.2% and was independent of tumor size. Most patients (85%) had erythema, which was severe in 24%. Nine patients discontinued because of skin reactions. Overall 82.1% of patients were satisfied or very satisfied with imiquimod ...