Atopic dermatitis (AD) is a common
disease affecting both children and adults. AD develops from a
complex interplay between environmental, genetic, immunological and
biochemical factors. Genetic factors predispose atopic subjects to
exaggerated T helper 2 responses and to a poorly efficient
epidermal barrier, which may be sufficient to initiate inflammation
in the skin and may favor allergic sensitization. Thus AD can
present with different clinical phenotypes. Nummular eczema is
among the more frequent nonconventional clinical presentations of
AD. Here we present a case of nummular atopic eczema in a
34-year-old man successfully treated with methotrexate...