Access Dermatology

Atopic dermatitis (AD) is a common disease affecting both children and adults. AD develops from a complex interplay between environmental, genetic, immunological and biochemical factors. Genetic factors predispose atopic subjects to exaggerated T helper 2 responses and to a poorly efficient epidermal barrier, which may be sufficient to initiate inflammation in the skin and may favor allergic sensitization. Thus AD can present with different clinical phenotypes. Nummular eczema is among the more frequent nonconventional clinical presentations of AD. Here we present a case of nummular atopic eczema in a 34-year-old man successfully treated with methotrexate...