Access Dermatology

CREST syndrome stands for calcinosis, Raynaud's syndrome, esophageal dysmotility, sclerodactyly and teleangiectasia. It is a special form of acral scleroderma, a limited cutaneous manifestation of systemic scleroderma. It is a chronic disease of the connective tissue that begins with an inflammatory phase and is followed by a fibrotic phase. The CREST syndrome is associated with the production of antinuclear antibodies against centromeres. In the treatment of this syndrome, prevention of cold, vasodilators and histamine H₂ antagonists or proton-pump inhibitors are used. We present the case of a middle-aged woman with typical skin lesions in predilection sites and positive laboratory findings...