Clinical Cases

CREST Syndrome

CREST Syndrome

Published:  04 July 2011


CREST syndrome stands for calcinosis, Raynaud's syndrome, esophageal dysmotility, sclerodactyly and teleangiectasia. It is a special form of acral scleroderma, a limited cutaneous manifestation of systemic scleroderma. It is a chronic disease of the connective tissue that begins with an inflammatory phase and is followed by a fibrotic phase. The CREST syndrome is associated with the production of antinuclear antibodies against centromeres. In the treatment of this syndrome, prevention of cold, vasodilators and histamine H2 antagonists or proton-pump inhibitors are used. We present the case of a middle-aged woman with typical skin lesions in predilection sites and positive laboratory findings...

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