Lichenoid drug reactions can be
caused by many drugs. The typical skin lesions occur on the trunk
and extremities as pruritic erythematous papules with confluence.
The biopsy specimen shows band-like lymphocytic infiltrate in the
upper dermis, hydropic degeneration of the basal cell layer,
necrotic keratinocytes and lichenoid interface dermatitis with some
eosinophils. The therapy involves discontinuation of the medication
that initiated the reaction. The skin lesions are treated with
topical agents containing corticosteroids. Most patients react well
to systemic corticosteroid therapy. Oral antihistamines are often
helpful to treat the itch. We present a case of an elderly woman
with typical lesions, positive history, characteristic histology
and a positive response to therapy...