Editorial Blog

Rediscovering Methotrexate
Josep Maria Mascaró

Rediscovering Methotrexate

Published:  01 July 2010


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In the late 1940s a chemical analogue of aminopterin called methotrexate was shown to be useful in the treatment of acute lymphoblastic infantile leukemia. The drug, a competitive inhibitor of dihydrofolate reduct...

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