Rediscovering Methotrexate

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Rediscovering Methotrexate

Josep Maria Mascaró
Professor Emeritus of the University of Barcelona, Spain, and Editor of Access Dermatology

Published: 01 July 2010

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In the late 1940s a chemical analogue of aminopterin called methotrexate was shown to be useful in the treatment of acute lymphoblastic infantile leukemia. The drug, a competitive inhibitor of dihydrofolate reduct...

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Last updated: Tuesday, November 29, 2011

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