The impact on the use of UK medical resources, costs and outcomes associated with the introduction of biological therapies (adalimumab, etanercept or infliximab) in patients with moderate-severe psoriasis was collated. Data were obtained from a sequential patient cohort for 12 months prior to and at least 6 months following initiation of treatment. Clinical outcomes were measured by the Psoriasis Area and Severity Index (PASI). The analysis comprised 76 patients completing 12 months of therapy; their mean age was 47 years (range 23-74) with a mean psoriasis duration of 26 years. Mean annual costs decreased by £1,682 (P = 0.028), while mean annual drug costs rose by £9,456 and the mean PASI ...