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Topical pimecrolimus, methylprednisolone aceponate and metronidazole gel in the treatment of seborrheic dermatitis: A randomized study

Topical pimecrolimus, methylprednisolone aceponate and metronidazole gel in the treatment of seborrheic dermatitis: A randomized study

 
 

An 8-week, randomized study investigated the effects of topical pimecrolimus cream 1%, methylprednisolone aceponate (MA) cream 0.1% and metronidazole gel 0.75% in the treatment of 64 patients with seborrheic dermatitis. The treatments were applied twice daily. Assessments were made at baseline and weeks 2, 4 and 8 using a 4-point severity scale (0 = absent, 4 = severe). At week 4 there was a statistically significant (P = 0.001) difference in favor of pimecrolimus versus the metronidazole group in mean severity, and between pimecrolimus and MA (P = 0.002). Regarding specific symptoms, pimecrolimus was significantly more effective than MA with regard to erythema and pruritus at weeks 4 and 8 (P ...

 
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