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Efficacy and safety of topical tacrolimus versus topical fluticasone in pediatric atopic dermatitis


A double-blind, noninferiority study compared the effects of 0.03% tacrolimus ointment versus 0.005% fluticasone ointment in 478 children (aged 2-16 years) with moderate to severe atopic dermatitis (AD). Patients were treated twice daily for 3 weeks and the primary endpoint was the percentage of patients achieving ≥60% reduction in the Eczema Area and Severity Index (EASI). At week 3, response rates were 86.3% and 91.5% in the tacrolimus and fluticasone groups, respectively; criteria for noninferiority were met. Secondary endpoints (patient/physician global assessments; pruritus severity; sleep and safety) showed no difference between treatments. Tacrolimus ointment 0.03% is a safe and effective treatment to control moderate to severe AD in children (Doss, N. et al. ...

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