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CD40 expression and correlation with disease severity in atopic dermatitis


CD40 expression in atopic dermatis (AD) skin lesions and on peripheral blood cells from AD patients was determined and correlations between CD40+ cells and AD disease severity were examined. The nature of CD40+ cells included CD1a+ and CD11b+ antigen processing cells (APCs). A correlation between serum PARC and IgE levels and the number of CD40+ cells in AD skin lesions was found. These findings suggest that CD40 is up-regulated in APCs and that strategies modulating CD40+ cells may be useful in AD patients (Oflazoglu, E. et al. Eur J Dermatol 2008, 18[5]: 527-533).

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