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Diagnosis of melanoma: From ABCD to in vivo confocal microscopy


Dermoscopy is a noninvasive tool which increases the diagnostic accuracy of melanoma and pigmented skin lesions by >20% compared with naked eye observations. Reflectance confocal microscopy (CM) provides images representing horizontal sections of epidermis and superficial dermis. With CM, contrast is provided by differences in refraction index of organelles and other structures, which appear bright thus contrasting with the background. It can distinguish between benign and malignant melanocytic lesions and may represent a missing link between clinicians and pathologists (Pellacani, G. 17th Congr Eur Acad Dermatol Venereol (EADV) (Sept 17-21, Paris) 2008, Abst SY01.2).

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