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Better response to cyclosporine therapy in psoriasis patients with weight loss

An interesting study from Verona University in Italy investigated whether 5-10% of body weight loss could increase the therapeutic response to a low dose of cyclosporine in obese patients with moderate to severe chronic plaque psoriasis. In a 24-week randomized, controlled, investigator-blinded, clinical trial involving 61 patients, the efficacy of daily cyclosporine (2.5 mg/ kg) combined with a low-calorie diet (intervention group) was compared with that of cyclosporine alone (control group) in obese patients (body mass index >30) with moderate to severe psoriasis. A PASI 75 response was achieved by 67% of patients treated with cyclosporine plus the low-calorie diet, compared with (29%) patients treated with cyclosporine alone (Gisondi, P. 5th Int ...