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CD5L and ApoE may be potential biomarkers of atopic dermatitis


A differential glycoprotein profiling of plasma studies was conducted in children with atopic dermatitis (AD) and healthy donors to identify the potential biomarkers of AD. The glycoproteomic results showed a differential expression of both CD5L and apolipoprotein E (ApoE) in plasma of children with AD; hence, whereas ApoE was down-regulated, CD5L was up-regulated. The researchers also determined that the up-regulation of CD5L in these children might cause eosinophilia by inhibiting apoptosis or promoting the proliferation of eosinophils. Although further studies are required, the findings obtained in this glycoproteomic analysis suggest that CD5L and ApoE may be potential biomarkers of AD (Kim, W.K. et al. Exp Mol Med 2008, 40[6]: 677).

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