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New data on the clinical course and urinary excretion of eicosanoids in patients with aspirin-triggered skin reactions

A long-term observational study evaluated the clinical course and urinary eicosanoids in aspirin-induced urticaria in 22 patients with chronic idiopathic urticaria and aspirin sensitivity who were asked to avoid the use of aspirin and other cyclooxygenase 1 (COX-1) inhibitors during the trial. During the 4-year follow-up, the frequency and severity of urticaria decreased. However, 14 out of 22 patients remained hypersensitive to aspirin with positive results in the aspirin provocation test. Moreover, in these patients, eicosanoid responses (i.e., increase in urinary levels of cysteinyl leukotriene E4 and in the prostaglandin [PG] D2 metabolite, 9 alpha 11 beta PGF2) after aspirin challenge were similar to those observed 4 years earlier. Researchers also found an ...