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Skin barrier dysfunction correlates with disease severity in AD

The potential role played by skin barrier function on the clinical severity of atopic dermatitis (AD) was assessed in a study conducted at Hokkaido University in Sapporo, Japan and the University of Dundee in the UK. Stratum corneum hydration and transepidermal water loss (TEWL) were used to compare barrier function in AD patients with or without mutations in the gene encoding for filaggrin (FLG) and in healthy controls. Compared to healthy controls, stratum corneum was significantly higher in patients with mutated FLG while TEWL was significantly lower in patients with nonmutated FLG. The clinical severity of AD, measured using the objective score of atopic dermatitis (OSCORAD) index, was significantly correlated with ...