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Tacrolimus ointment in the treatment of allergic contact eyelid dermatitis

A 2-month, prospective, open-label, noncomparative trial was conducted in 20 patients with allergic contact eyelid dermatitis to evaluate the efficacy and safety of tacrolimus 0.1% ointment. Dermatitis was graded by patients and clinicians at baseline, and at 30 and 60 days using a 4-point assessment scale regarding erythema, edema, scaling/dryness, lichenification, fissuring, pruritus (patient only) and burning/stinging (patient only). All investigator-graded symptoms improved significantly from baseline at day 30 apart from fissuring. At 60 days there was no further improvement in these investigator-related parameters. On the patient-graded parameters, these improved significantly by day 30 with a trend for improvement at the end of 60 days for burning and pruritus. Burning and itching ...