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Efficacy of twice-weekly tacrolimus ointment in pediatric atopic dermatitis


A post-hoc analysis was undertaken of children with moderate-severe atopic dermatitis (AD) who had completed a 12-month randomized, double-blind trial with tacrolimus ointment 0.03% with a twice-weekly (maintenance regimen) or vehicle (standard regimen). The primary endpoint was the number of major flares (exacerbations that required tacrolimus ointment for > 7 days to treat an Investigator's Global Assessment score of 3-5 during the disease control period). During the 12-month trial, 46.2% of patients receiving the maintenance regimen had no flares versus 23.1% of those on a standard regimen. The number of days of exacerbation were less with maintenance (42.3 days) versus standard (68.9 days) regimens. The time to first flare was also significantly ...

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