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Immunogenicity of rituximab in patients with severe pemphigus


The development of anti-rituximab antibodies was determined in 11 pemphigus patients before and 3, 9 and 15 months after treatment with rituximab. In two patients, antibodies were detected and only a partial remission was obtained. Of nine patients without antibodies, all lesions healed in five, and partial remissions were seen in four. Antibodies to rituximab may thus be associated with a less than optimal outcome (Schmidt, E. et al. J Invest Dermatol 2009, 129 (Suppl. 2): 24, Abst 127).

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