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Platelet P-selectin as a biomarker of inflammation in psoriasis


The expression of P-selectin in platelets from 46 psoriasis patients, 41 healthy controls and 100 other patients with inflammatory skin disease was studied. Before treatment, P-selectin expression was significantly increased in psoriasis patients versus controls (3.46% vs. 1.46%; P < 0.001). Following antipsoriatic therapy, Psoriasis Area and Severity Index (PASI) scores fell from 17.2 to 5.45 as did P-selectin median levels from 3.61% to 1.48% (P < 0.01). Changes in the PASI before and after antipsoriatic therapy correlated with changes in P-selectin expression (R = 0.31; P < 0.05). P-selectin expression correlated well with the erythema (R = 0.52; P < 0.01) and infiltration (R = 0.35; P < 0.05) components ...

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