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Psoriasis and risk of incident cancer: An observational study

A population-based observational study in 33,760 patients with psoriasis and 34,001 matched controls evaluated the risk of incident cancer in psoriasis patients. Among the population of 67,761 patients, 1,703 had cancer, of whom 54% had psoriasis. Incidence rate ratios for lymphohematopoietic and pancreatic cancers were 1.81 and 2.20, respectively. In a nested case-control analysis the adjusted odds ratio (AOR) for cancer overall was 1.50 for psoriasis with a duration of 4 years or more, and 1.53 for patients receiving systemic therapy. Psoriasis patients may thus have an increased risk of incident cancer and bladder/kidney, and colorectal cancer risk may also be increased with longer disease duration (Brauchli, Y.B. et al. J ...