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ADAM 10 is upregulated in melanoma metastases compared with primary melanomas


The expression of ADAM10 (a disintegrin and metalloproteinase 10) was characterized in melanoma cells in vitro and in vivo. ADAM10 was significantly elevated (P = 0.04) in metastasizing melanomas compared with those of primary origin. Overexpression of ADAM10 induced the migration of melanoma cells and correlated with increased cell proliferation. Knockdown of cellular L1-CAM (L1-adhesion molecule) decreased the migration of melanoma cells and abrogated their chemoresistance due to cisplatin. ADAM10 and L1-CAM have important functions in melanoma progression and thus present putative targets for therapeutic intervention (Lee, S.B. et al. J Invest Dermatol 2010, 130: 763).

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