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Development of atopic dermatitis may be affected by gene-environment interactions

A questionnaire survey was conducted in 2008 to investigate the prevalence and risk factors of atopic dermatitis (AD) in primary- and middle-school children in Seoul, Korea. A modified International Study of Asthma and Allergies in Childhood (ISAAC) survey was conducted in 5,036 primary-school and 4,607 middle-school children. Risk factors were included for family history of allergic diseases and environmental risk factors for AD. Results were compared with those for 1995 and 2005 surveys. Those with a diagnosis of AD at any time increased from 19.7 and 27.5% in 1995 and 2000, respectively to 29.4% in 2008. Treatment of AD in the last 12 months was 9.3, 13.5 and 13.6% in 1995, ...