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Enteric-coated mycophenolate sodium in the treatment of refractory pemphigus

An 18-month, prospective, observational, open-label study assessed the effects of enteric-coated mycophenolate sodium 1440 mg/day in combination with prednisone 75 mg/day in 10 patients aged 18-75 years with active refractory pemphigus vulgaris (PV) or pemphigus foliaceous (PF). In the majority of cases (90%), disease progression was inhibited between 30-45 days. At 18 months, 8 out of 9 patients had clinically quiescent disease and the mycophenolate sodium was discontinued in 2 patients due to remission. One patient showed no response to treatment. Approximately half of the patients (4/9) reduced the mycophenolate sodium dose to 720 mg/day by 6 months and the mean prednisone dose was also reduced to 25 and 15 mg/day ...