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Risk of second primary malignancies following cutaneous melanoma diagnosis: A population-based study


A U.S. population-based study calculated the incidence rates and relative risks for the development of different second primary malignancies (SPMs) occurring in 16,591 cutaneous malignancy (CM) survivors during 1.3 million person-years of observation from 1973-2003. Compared with the general population, CM survivors had a 32% increased risk of any SPM and a significantly increased risk of 13 different cancers. These comprised, in decreasing order of standardized incidence ratio (SIR): skin melanoma, soft tissue, melanoma of eye and orbit, nonepithelial skin, salivary gland, bone and joint, thyroid, kidney, chronic lymphocytic leukemia, brain and nervous system, non-Hodgkin's lymphoma, prostate and female breast. The finding of an increased SIR for skin melanoma is perhaps unsurprising, ...

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