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Cacipotriol/betamethasone gel compared with its individual components or vehicle alone in psoriasis vulgaris


An 8-week, international, multicenter, prospective, randomized, double-blind, four-arm, parallel-group study compared the efficacy and safety of calcipotriol/betamethasone (C/B) gel, calcipotriol, betamethasone or vehicle in 364 patients with psoriasis vulgaris (PV). The primary endpoint was the percentage of responders at weeks 4 and 8, according to the Investigator's Global Assessment (IGA). Responders were patients who had a "clear or minimal" assessment; for patients who were mild at baseline, they were required to be graded as "clear". Secondary assessments included the percentage change from baseline to weeks 4 and 8 in the Psoriasis Area and Severity Index (PASI). The percentage of responders at week 8 was 27.2, 16.9 (P = 0.027), 11.4 (P = ...

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