Core Papers

Behçet’s Disease

Behçet’s Disease

Published:  04 August 2007



Behçet's disease (BD) is a chronic, inflammatory multisystemic condition of unknown etiology. It is clinically characterized by recurrent orogenital ulcerations and skin eruptions; ocular manifestations; arthritis; vasculitis and in some cases neurological and large vessel involvement. Etiology has not been defined, but genetic, environmental, viral, bacterial and immunological factors have been proposed as causative agents. Treatment includes colchicine, thalidomide, steroids and immunosuppressive agents and it is based on the severity of systemic manifestations, such as severe ocular symptoms, central nervous system involvement, arterial aneurysms and thrombosis of themajorveins. Mortality is related to major system involvement. In this article thed ifferent clinical features, the multiple faces of BD, and treatment modalities are summarized.

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