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LCE3C_LCE3B gene deletion associated with psoriasis in northern Chinese patients
LCE3C_LCE3B gene deletion associated with psoriasis in northern Chinese patients
Although deletion of the LCE3C_LCE3B gene cluster is associated with increased psoriatic risk in European populations, the correlation remains unclear in northern Chinese populations. A study of 970 northern Chinese patients with psoriasis and 1,064 unrelated healthy controls was conducted to assess the frequency of this gene deletion in the two groups. There was a significantly increased frequency of the gene deletion in patients (63.66%) versus controls (59.35%; P = 0.0048). Thus LCE3C_LCE3B gene deletion is an important risk factor in psoriatic pathophysiology (Xu, L. et al. Br J Dermatol 2011, 165: 882).
Last updated: Tuesday, November 29, 2011
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ISSN 2013-8202
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