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Incidence of Merkel cell carcinoma has tripled: A review of epidemiology and clinical management
Incidence of Merkel cell carcinoma has tripled: A review of epidemiology and clinical management
A review of Merkel cell carcinoma (MCC), its epidemiology, pathogenesis, clinical aspects and treatment has been published. MCC is estimated to have an incidence of 0.18-0.41/100,000 persons and the age-adapted incidence has tripled from 1986-2001, with a statistically significant annual incidence of 8%. MCC usually develops rapidly in sun-damaged skin giving a red or violaceous firm nodule with a smooth, shiny surface. Recent research has implicated a polyomavirus (Merkel cell polyomavirus or MCV) in the pathogenesis of MCC. Treatment involves surgical excision, lymphadenectomy, radiotherapy or chemotherapy or combinations thereof. The 5-year survival rate varies from 18-79% dependent upon the stage, primary tumor site, node status and the presence of metastases (Schroma, D. ...
Last updated: Tuesday, November 29, 2011
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ISSN 2013-8202
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