Spectrophotometric intracutaneous analysis (SIAscopy) was compared with dermoscopy in the diagnosis of pigmented basal cell carcinoma (PBCC). Twenty-one PBCCs were analyzed and investigated by SIAscopy and dermoscopy. This study showed that SIAscopy had no advantage over dermoscopy and moreover, may be misleading in that some features previously reported for melanoma were shown on SIAscopy (Terstappen, K. et al. Acta Derm Venereol 2007, 87(3): 238-242).