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ADAM33 polymorphism associated with the risk of AD

ADAM33 polymorphism associated with the risk of AD


A cross-sectional, epidemiological study assessed for the first time the association between single nucleotide polymorphisms (SNPs) in the ADAM33 gene and the risk of atopic dermatitis (AD). The analysis of seven SNPs in 140 patients with AD and 258 controls revealed that only rs2853209 correlated with a risk of AD. When comparing the proportions of major allele homozygotes (TT), heterozygotes (TA) and minor allele homozygotes (AA), the investigators observed a decreased risk of AD (OR 0.26) in patients carrying the rs2853209 A allele as opposed to those carrying any other haplotypes. Although these data suggest an association between ADAM33 polymorphism and AD, further studies with larger sample size are required to determine ...

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