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A controlled study of topical tacrolimus in vitiligo

A 6-month, controlled, randomized, observer-blinded study assessed the effects of once-daily versus twice-daily topical tacrolimus ointment 0.1% in 17 patients (aged 10-61 years) with vitiligo. Two similar lesions in each patient were randomized to either once- or twice-daily treatment with tacrolimus ointment. In 10 patients, a third patch was left untreated to serve as a control. Repigmentation was graded as none (0%), poor (1-25%), moderate (26-50%), good (51-75%) or excellent (76-100%). Fifteen patients completed the study. Twice-daily therapy for 6 months produced some repigmentation in 10 of 15 (67%) lesions, while once-daily treatment did so in 7 of 15 (46%) of lesions. Moderate repigmentation only occurred in one untreated control lesions; the ...