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Platelet activation in patients with psoriasis: Changes in various platelet markers

Plasma levels of platelet-derived microparticles (PDMPs) and soluble P-selectin (sP-selectin) were measured in 21 patients with psoriasis (aged 28-78 years) and 22 age- and gender-matched controls. Correlates of these markers with the Psoriasis Area and Severity Index (PASI) were measured. Plasma PDMPs and sP-selectin were significantly higher in psoriasis patients versus controls (P < 0.01). PDMPs were significantly correlated with the PASI (r = 0.55; P < 0.05) but not sP-selectin levels. However, after treatment the PASI, PDMPs and sP-selectin levels fell significantly (all P < 0.05 vs. baseline). Platelet counts did not differ between patients and controls. Plasma PDMPs may be a useful proxy measure of psoriatic disease activity (Tamagama-Mineoka, R. ...