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Platelet P-selectin reflects cutaneous inflammation: Possible utility to monitor treatment response in psoriasis

Platelet P-selectin reflects cutaneous inflammation: Possible utility to monitor treatment response in psoriasis

 
 

A German study evaluated platelet P-selectin as a biomarker for cutaneous inflammation in 147 subjects with an inflammatory or infectious skin condition. These comprised moderate-severe plaque psoriasis (n = 47); localized dermatitis (n = 28); widespread dermatitis (n = 25); urticaria (n = 13); bacterial infection (n = 13); leg ulcers (n = 10) and prurigo (n = 11). Forty-one patients without skin symptoms served as controls. A significant increase in platelet P-selectin was seen in patients with inflammatory or infectious skin conditions (3.01 vs. 1.46%; P < 0.000001). Platelet P-selectin and the Psoriasis Area and Severity Index (PASI) were highly correlated in psoriasis (r = 0.51; P < 0.000001) as ...

 
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