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Riluzole attenuates melanoma cell transformation

Riluzole attenuates melanoma cell transformation


The effects of glutamate receptor blockade on melanocytic transformation were studied in vitro. Riluzole, an inhibitor of glutamate signaling or the noncompetitive metabotropic glutamate receptor-1 (GRM1) antagonist, BAY 36-7620 induced considerable inhibition of colony formation and invasion in GRM1-expressing melanoma lines. No effect was seen on a GRM1-negative melanoma line. Moreover, riluzole and BAY 36-7620 inhibited fresh melanoma tumor growth when cultured on a nylon mesh. These agents were much less effective in preventing cell overgrowth from normal moles. These data indicate GRM1 to be a valid target for drug development in melanoma research (Le, M.N. et al. J Invest Dermatol 2010, 130: 2240).

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