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Phototherapy may lead to normalization of cyclin D1 and p16 in psoriasis

Phototherapy may lead to normalization of cyclin D1 and p16 in psoriasis

 
 

The expression of cyclin D1 and p16 was evaluated before and after 24 sessions of psoralen ultraviolet A (PUVA) therapy (n = 11) or narrowband UVB (NB-UVB) therapy (n = 14) in patients with psoriasis and a mean age of 44 years. Ten healthy age- and gender-matched controls were also included in the study. Prephototherapy, the mean value of cyclin D1 in psoriasis patients was significantly (P < 0.001) higher than in controls while p16 levels were significantly lower (P < 0.001). Following treatment, cyclin D1 levels decreased significantly (P < 0.01) and p16 levels significantly increased (P < 0.001). Up- and downregulation of these two agents may play a role ...

 
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