History
An 85-year-old woman was referred with a 5-year history of a
nonhealing ulcer on the right lower leg. The ulcer had not
responded to consistent conservative treatment, compression therapy
and split-thickness skin grafting. Her medical history was
remarkable for chronic venous insufficiency and posttrombotic
syndrome of the right lower leg. Additionally, she had
hypertension, arrhythmia, myocardial hypertrophy, glaucoma and type
2 diabetes mellitus. Her medications included nitroglycerin,
methyldigoxin, atenolol, amlodipine, aspirin and metformin. The
patient denied any arsenic exposure, irradiation or burns. She had
no positive history of skin cancer.
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