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Clinical relevance of Malassezia IgE antibodies in pediatric atopic dermatitis

The relationship between the presence of immunoglobulin E (IgE) antibodies to Malassezia spp., age, SCORing Atopic Dermatitis (SCORAD) index, total IgE levels, polysensitization diversity and dermal colonization was determined in 112 children with atopic dermatitis (AD), aged 1-15 years. Forty-two per cent of children (aged > 5 years) had IgE Malassezia spp. antibodies as did every second patient aged 6-15 years. IgE antibodies were found in 42.5% of all AD patients and the levels increased with increasing SCORAD scores. IgE-antibody correlated with total IgE levels and polysensitization. No correlation was found between diversity of yeast colonization and the prevalence of IgE antibodies to Malassezia spp. (Golysheva, E. et al. 29th Congress Eur Acad ...