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Detection of subclinical and clinical actinic keratosis during imiquimod treatment

A randomized, double-blind, vehicle-controlled, parallel-group study in 12 patients with actinic keratosis (AK) compared cross-polarized light (CPL) and fluorescence diagnosis (FD) for the ability to detect subclinical lesions before and 24 weeks after imiquimod 5% cream (n = 9) or vehicle (n = 3). Biopsy results were taken before and after using imiquimod or vehicle to assist validation. Patients were assessed for clinical and subclinical lesions at baseline and weeks 4, 8, 12 and 20. Imiquimod patients had significantly lower AK lesion counts at weeks 12 and 20 compared with baseline versus vehicle. Lesion counts were significantly increased using the CPL method compared with clinical counting with imiquimod at baseline (P ...