The European S-3 guidelines for the systemic treatment of psoriasis vulgaris were recently published. Regarding treatment options, these were discussed under the headings of mode of action, posology, efficacy, safety and tolerability, contraindications, drug interactions, overdosage, special considerations, combination therapy, and pre-, peri- and post-treatment tests that should be performed. The agents discussed comprised methotrexate, ciclosporin, retinoids, fumaric acid esters, adalimumab, etanercept, infliximab, efalizumab and photodynamic therapy (Pathirina, D. et al. JEADV 2009, 23(Suppl.2): 5).