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Methylthioadenosine phosphorylase is predictive for response to interferon in malignant melanoma

Methylthioadenosine phosphorylase (MTAP), a suggested biomarker of malignant melanoma has prognostic value and may predict response to adjuvant interferon therapy in melanoma patients. A cohort of 392 patients with primary MM (n = 297), melanoma metastases (n = 34) and benign nevi (n = 61) had their MTAP and signal transducer and activator of transcription 1 (STAT1) activity measured. MTAP expression significantly decreased in melanoma and metastatic melanoma patients versus those with benign nevi (P < 0.0001); STAT1 expression significantly increased (P < 0.001). In melanoma patients, loss of MTAP expression was significantly related to Clark level and tumor thickness. STAT1 immunoreactivity was significantly related to gender and tumor thickness. Subgroup analysis revealed ...