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Platelet-derived growth factor beta as a tool in the diagnosis of dermatofibrosarcoma protuberans

Platelet-derived growth factor beta as a tool in the diagnosis of dermatofibrosarcoma protuberans

 
 

The genetic rearrangements in 10 patients with dermatofibrosarcoma protruberans (DFSP) were examined. Of the 10 patients, 9 had a collagen type 1 alpha 1 (COL1A1)/platelet-derived growth factor beta (PDGFB) fusion transcript. In two cases there was a fusion between the ends of exons 6, 8 and 29; in three cases at the end of exons 38, 25 or 47 and the start of exon 2 of the PDGFB gene. All samples had significantly higher expression of this gene compared with normal skin or dermatofibroma (Muchemma, F.C. et al. Clin Exptl Dermatol 2010, 35(3): 295).

 
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