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Bedding dust from atopic dermatitis patients contains high levels of human TLR4 ligands

Bedding dust from atopic dermatitis patients contains high levels of human TLR4 ligands

 
 

Higher levels of human TLR4 ligands (hTLR4-L) were detected in bedding dust samples obtained from patients with moderate/severe atopic dermatitis (AD) compared to non-AD patients in a recent study performed at the University of Colorado. AD is also associated with high burdens of Staphylococcus aureus. hTLR4-L was quantified using a novel hTLR4/MD2-CD14-transfected cell line with a luciferase reporter system in conjunction with a conventional limulus amebocyte lysate (LAL) assay in 29 bed or bedroom dust samples. The levels of hTLR4-L in bedding samples correlated with LAL levels, while floor dust levels did not show any differences between moderate/severe AD and non-AD samples. The observed association of AD with high hTLR4-L in ...

 
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