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Systemic methotrexate in severe childhood psoriasis

Systemic methotrexate in severe childhood psoriasis


An Indian retrospective chart study analyzed the efficacy and safety of methotrexate in severe childhood psoriasis. Records of 24 patients aged <18 years from 1993-2006 were retrieved from one institute. Response to treatment was graded as good (50-75% decrease in the Psoriasis Area and Severity Index, or PASI) and excellent (>75% decrease in the PASI score). Laboratory tests to monitor methotrexate toxicity were done at regular intervals. Response to treatment was "excellent" in 22 cases and the mean time to 50% reduction in the PASI was 5.1 weeks. The duration of remission varied from 1.5 months to 3 years based on 9 evaluable patients. Mild side effects were observed in 9 patients ...

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