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Staphylococcus aureus suppression with sodium hypochlorite baths and intranasal mupirocin decreases atopic dermatitis severity

A 3-month, randomized, investigator-blinded, placebo-controlled study of 31 children and adolescents (aged 6 months-17 years) with moderate to severe atopic dermatitis (AD) was conducted. It investigated whether suppression of Staphylococcus aureus growth by sodium hypochlorite (NaClO) and intermittent intranasal mupirocin could decrease eczema severity. The primary endpoint was the decrease in Eczema Area Severity Index (EASI) score from baseline to endpoint. NaClO baths comprised one-quarter cup of a 6% solution in half a bathtub of water (0.0005% solution) at least twice weekly. The placebo group bathed in water and received intranasal petrolatum ointment instead of mupirocin. Twenty-two patients completed the study. The treatment group had significantly decreased EASI scores at 1 and ...