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Autoantibodies against tyrosine hydroxylase higher patients with generalized vitiligo

Autoantibodies against tyrosine hydroxylase higher patients with generalized vitiligo

 
 

The prevalence of autoantibodies to tyrosine hydroxylase (TH) in patients with nonsegmented (generalized) vitiligo (n = 79), segmented vitiligo (n = 8) or other autoimmune diseases without vitiligo (n = 91) was investigated. Sera from 28 healthy subjects were also examined. Only patients with nonsegmental vitiligo had autoantibodies to TH, and these were found in 18/79 patients (23%). This prevalence was significantly higher than that seen in controls (P = 0.003). Sixty-four patients had active vitiligo, and TH autoantibody prevalence was significantly higher in these patients compared to those with stable disease (P = 0.0009) (Kemp, E.H. et al. Exptl Dermatol 2010, 20: 35).

 
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