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Elevated platelet activation markers in atopic dermatitis

Elevated platelet activation markers in atopic dermatitis


The role of various platelet markers was investigated in 34 atopic dermatitis (AD) patients and compared with 16 healthy controls. The markers were platelet-derived microparticles (PDMP); soluble P-selectin (sP-selectin), beta-thromboglobulin (BTG) and platelet factor 4 (PF4). The relationship between these markers and the SCORing Atopic Dermatitis index (SCORAD), eosinophilia, serum IgE and serum lactate dehydrogenase was investigated. Plasma levels of PDMP, sP-selectin, BTG and PF4 were significantly increased in AD patients versus controls. Plasma levels of sP-selectin and PDMP correlated with the SCORAD index. The latter 2 markers may be useful as a proxy measure of AD severity (Tamagawa-Mineoka, R. et al. 5th Int Symp Atopic Dermat (May 11-13,Kyoto) 2008. Abst 120C). --> -->

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