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Tacrolimus and ceramide-dominant emollient show similar effects in atopic dermatitis

Tacrolimus and ceramide-dominant emollient show similar effects in atopic dermatitis

 
 

Patients with atopic dermatitis (AD) experience increased transepidermal water loss (TEWL) and downregulated antimicrobial peptides (AMPs) as a consequence of skin barrier dysfunction and production of inflammatory cytokines, respectively. Tacrolimus and ceramide-dominant emollients are effective in correcting the function of skin barrier factors and preventing the production of inflammatory cytokines, respectively. A recent study performed by scientists in South Korea aimed to investigate the potential relationship between antimicrobial and skin barrier factors and the development of AD by measuring changes in AMPs and TEWL following topical application of tacrolimus and ceramide-dominant emollients in biopsy samples from AD patients. Patients (n = 3) were treated with tacrolimus in one lesion and ceramide-dominant emollient ...

 
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