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Tacrolimus and transformation growth factor beta act synergistically on Langerhans cell transformation

Tacrolimus and transformation growth factor beta act synergistically on Langerhans cell transformation

 
 

The effects of tacrolimus and transformation growth factor beta (TGF-beta1) on Langerhans cell (LC) differentiation of their epidermal precursors were studied. Tacrolimus and TGF-beta1 act synergistically on LC generation and the expression of CD40, CD80, CD86, CD83 and MHC-II. The combination stabilizes TGF-beta receptor II expression and decreased LC stimulatory capacity towards T-cells. The therapeutic effects of tacrolimus may depend on adjusting the balance of the dendritic cell population to favor LC formation (Kwiek, B. et al. J Allergy Clin Immunol 2008, 122[1]: 126-132).

 
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