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Family history and autoimmunity more common in nonsegmental than segmental vitiligo

Family history and autoimmunity more common in nonsegmental than segmental vitiligo

 
 

A single-center, prospective, observational study of 213 patients aged 17 years or younger with a confirmed diagnosis of segmental vitiligo (n = 59) or nonsegmental vitiligo (n = 142) was conducted to compare factors involved with each subtype. Twelve patients had mixed vitiligo. No significant differences between age, gender or age of onset existed between the two subtypes. Halo nevi, a positive family history of vitiligo and a marked familial autoimmunity background were more common in nonsegmental than segmental vitiligo (odds ratios [ORs]: 7.58, 2.25 and 2.22, respectively; P < 0.01, P = 0.02, P = 0.01, respectively). Inflammatory features are strongly linked to nonsegmental vitiligo together with a familial background of ...

 
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